Venkatesh Murthy

Department of Molecular and Cellular Biology
Harvard University
Biological Laboratories, Room 4027
16 Divinity Ave., Cambridge, MA 02138

tel: (617) 496-4833; fax: (617) 495-9300

Research Interests and Directions:

The vast capacity of the brain to process and store information arises from the large number of neurons and their synaptic connectivity.  Research in my laboratory is motivated by a desire to understand how neural circuits process information and how they adapt to changing conditions.

We develop and use novel optical and physiological methods in the living animal to seek answers to the following general questions in the main olfactory system of rodents:

*How is odor information represented in the early stages of the olfactory system?
*What is the logic of functional synaptic circuits in the early stages of the olfactory system?
*How is information processing affected by different brain states - sleep, wakefulness and neuromodulation?
*How are functional circuits in the olfactory system regulated by odor experience?

Selected Publications:

Blauvelt, D.G., Sato, T.F., Wienisch, M., and Murthy, V.N. 2013.  Distinct spatiotemporal activity in principal neurons of the mouse olfactory bulb in anesthetized and awake states. Front Neural Circuits. 7:46.

Markopoulo,s F., Rokni, D., Gire, D.H., and Murthy, V.N. 2012.  Functional properties of cortical feedback projections to the olfactory bulb. Neuron. 76(6):1175-88.

Murthy, V.N. 2011.  Olfactory maps in the brain.  Ann. Rev. Neurosci. 34:233-258.

Dhawale, A.K., Hagiwara, A., Bhalla, U.S., Murthy, V.N* and Albeanu, D.F.* 2010.  Non-redundant odor coding by sister mitral cells revealed by light addressable glomeruli in the mouse.  Nature Neurosci. 13:1404-1412. (* co-senior authors).

Petzold, G.C., Hagiwara, A. and Murthy, V.N. 2009. Serotonergic modulation of odor input to the mammalian olfactory bulb.  Nature Neurosci. 12:784-791.

Soucy, E.R., Albeanu, D.F., Fantana, A.L., Murthy, V.N.** and Meister, M.** 2009. Precision and diversity in an odour map on the olfactory bulb.  Nature Neurosci. 12:210-220. (* co-senior authors)

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